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Individuals with the following conditions should be considered higher-risk and would likely require specialist oversight: Established cardiovascular disease : patients with atherosclerotic cardiovascular disease may derive metabolic benefit from weight loss, but the modest increase in heart rate and haemodynamic changes associated with this drug class warrant careful monitoring

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In agreement, another study has demonstrated that serum levels of GSH-Px were higher on day-7 and 14 after Se supplementation in ARDS patients