Recently, PCBP2 was also identified as an iron chaperone for ferritin, conferring increased iron storage when co-expressed in yeast and manifesting decreased iron storage when depleted from human Huh7 cells (Leidgens et al., 2013)
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264 Therapeutic targeting of the UPR and ERAD in cancer IRE1 inhibitors UPR signaling and ERAD are critical adaptive pathways that allow cancer cells to survive chronic ER stress
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