glp-1 course Therapy for Patients with Obesity GLP-1-Based Therapies: Mechanisms of Action,

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A small trial including 8 patients with T1D showed improved postprandial hyperglycemia despite 20% insulin dose reduction ( 5 Cardiovascular and renal outcomes with GLP-1RA in T1D In patients with T2D, large RCT studies have shown that GLP-1RA treatment reduces the risk of cardiovascular and renal outcomes ( 6 Practical issues when prescribing GLP-1RA in T1D GLP-1RA are not currently approved for treatment of T1D, but they may still be covered by insurance if prescribed to treat obesity in these patients (although insurance coverage for obesity remains limited)

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Lengsfeld S, Burkard T, Meienberg A, Jeanloz N, Vukajlovic T, Bologna K, Steinmetz M, Bathelt C, Sailer CO, Vogt DR, Hemkens LG, Speich B, Urwyler SA, Kuhne J, Baur F, Lutz LN, Erlanger TE, Christ-Crain M, Winzeler B

1 In Vitro and in Vivo Pharmacology Melanotan II has been extensively studied for its pharmacological effects both in vitro and in vivo, demonstrating significant melanotropic activity

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