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Since DA-resistance of prolactinomas has been associated with increased invasiveness and aggressiveness of these tumors ( Up to now, no data are present in literature about the effects of FLNA expression levels on pituitary cell migration and invasion, and further studies are required to test a possible contribution of FLNA alterations in the invasiveness, aggressive behavior, and recurrences of pituitary tumors

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The difference isn't marginal

Noonan EJ, Place RF, Giardina C, Hightower LE: Hsp70B' regulation and function

Digital versus physical logs Either works