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JAMA 1998;280:605613

With the increasing use of semaglutide, clinicians should maintain a high index of suspicion for unexplained liver enzyme elevations, particularly following dose adjustments

It activates both receptor pathways simultaneously

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I was expecting to see more GI side effects with the higher dose, but it wasn't too much higher--70.8% at 7.2 mg vs 61.2% at 2.4 mg vs 42.8% with placebo, mostly mild an self-limited