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Cigarette butts make up nearly 88% of litter smaller than four inches, according to Keep America Beautiful

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When inflammation occurs, multiple inflammatory signaling pathways are activated, such as p38 MAP kinase (p38 MAPK), phosphatidylinositol-3-kinase (PI3K), and janus kinase/signal transducer and activator of transcription (JAK/STAT) [103]

Table 4 Associations* between SBP, DBP and hypertension and smoking pack-years, cigarettes/day and alcohol consumption/day in each group of current, past and never smokers for men (N=133950) and for women (N=156963) Figure 2 Linear regressions between SBP and DBP with smoking pack-years and cigarettes per day in men and women current smokers Figure 3 Hypertension prevalence among men and women current smokers according to: A) subgroups of number smoking pack-years, and B) subgroups of number cigarettes per day Among women current smokers, a significant association was observed between SBP and smoking pack-years [Model 3: B=0.04 (0.01), p 30 smoking pack-years showed higher proportion of hypertension (Figure 3)