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The compound has high potency and affinity for hMC4R (EC 50 = 0.27 nM) with reduced activity on hMC1R (EC 50 = 5.8 nM) and hMC3R (EC 50 = 5.8 nM) ( Table 1 ) (45)

Whether retatrutide's existing glucagon-receptor activation makes this additive or redundant is unstudied

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