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Taking the most basic example of a 2-arm trial of GLP-1 vs placebo, if the intervention reduced the risk of all cancers by an optimistic 25%, it would still require over 7000 participants in each arm under perfect follow-up and adherence, to give 90% statistical power to detect the small absolute reduction of 2% between intervention and control, equating to a number needed to treat of 50

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These observations were further supported by pathway analyses confirming the strong annotations related to NMDA receptor signalling (Fig

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