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2) Oxidative stress: increased production of ROS and lipid peroxides due to impaired antioxidant defenses (e.g., reduced GPX4 activity) leads to oxidative damage and cell death
Although GLP-1 RAs by themselves have a low risk of hypoglycemia, when used in combination with sulfonylureas and/or insulin, some experts recommend lowering the dose of sulfonylureas and short-acting and low-acting pancreatic islet analogs before or during the use of GLP-1 RAs (Romera et al., 2019
Nat Chem Biol, 2015
S.WeirV.ZhangY.CaffreyA.RichM
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Inflammatory and apoptotic regulatory activity of tanshinone IIA in helicobacter pylori-infected cells
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