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Proton pump inhibitor and histamine 2 receptor antagonist use and vitamin B12 deficiency
The ability of hydroxocobalamin to rapidly scavenge and detoxify cyanide by chelation has resulted in several acute animal and human studies using systemic hydroxocobalamin doses at suprapharmacological doses as high as 140 mg/kg to support its use as an intravenous (IV) treatment for cyanide exposure
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These medications are contraindicated during pregnancy and breastfeeding, as noted in their respective Summary of Product Characteristics
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