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As we age, NAD levels naturally decline, leading to reduced cellular function and an increased accumulation of cellular damage

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Zinc Depletion Long-term or frequent high-dose glutathione supplementation can reduce zinc levels in the body

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In addition to the Leu198Leu genotype in the GPx1 gene, the Ala16Ala genotype in the manganese superoxide dismutase ( MnSOD ) gene, the most significant enzyme that protects against ROS in the human body [90], was also associated with an increased risk of breast cancer [91]