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The protective effects of GLP-1 RAs against cardiovascular events have been demonstrated in several studies, thus supporting their application in patients with heart failure with preserved ejection fraction and DM2 ( Taken together, GLP-1 is a major metabolic and regulatory hormone, with many potential therapeutic implications beyond glycemic control, encompassing cardiovascular protection, enhanced renal function, and the potential benefits in hepatic disease

According to the standard two zero two algorithm protocol for long acting analogues such as insulin glargine or degludec the recommended starting dose is ten units or zero point one to zero point two units per kilo per day administered in the evening [Pocket Manual Terapia]

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The discomfort usually plateaus around day 10-14, then gradually decreases as your digestive system adapts

While such long-acting analogs could potentially be a headwind for Stevanatos volume, they would significantly enhance the visibility of future cash flows by stabilizing patient retention