GLP-1 stands for glucagon-like peptide-1, a naturally occurring hormone produced in the gut that plays a critical role in regulating blood sugar and appetite
When weight loss occurs gradually, skin has time to contract and adapt to reduced underlying volume
ToyamaTNeuenBLJunMOhkumaTNealBJardineMJet al
In summary, incretin receptor agonists demonstrate consistent anti-fibrotic effects in vivo , reducing hepatic stellate cell activation, oxidative stress, and collagen deposition in animal models, and improving fibrosis outcomes in clinical MASLD and MASH studies
In general, GLP-1 and glucagon are believed to antagonize their respective effects on glucose homeostasis
Examples of monoclonal antibodies include trastuzumab (Herceptin), dupilumab (Dupixent), pembrolizumab (Keytruda), and ocrelizumab (Ocrevus)