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While there have been no previous cases of dermal hypersensitivity reactions to semaglutide reported in the literature, there have been reported cases for other drugs in the GLP-1 receptor agonist class

Acne occurs when hair follicles become clogged with oil and dead skin cells, leading to pimples, blackheads, whiteheads, or cysts

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These findings informed the phase II and III study recommendations to administer oral semaglutide in the fasting state with up to 120 mL water and wait for 30 min post-dose before eating or ingesting other oral medications [39, 57, 59,60,61,62]

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