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A Novo Nordisk spokesperson pointed out that NAION is not listed on approved labels as an adverse drug reaction for the marketed formulations of semaglutide. They also noted limitations in the Mass Eye and Ear study, such as its small and non-randomized sample group

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Serious adverse events are exceptionally rare lipotropic amino acids and water-soluble vitamins carry minimal toxicity risk at standard dosing

However, these products are not regulated for quality, safety, or consistency, and purchasing them for self-administration poses significant health risks

Because it is a peptide naturally present in the human body, it is thought to be well tolerated at low concentrations