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These systems allow targeted delivery of therapeutic nucleic acids, such as GPX4 mRNA to enhance antioxidant capacity or ACSL4-siRNA to limit peroxidation-prone lipid pools (164), enabling cell-type-specific suppression of ferroptosis

Abbreviations ABTS: 2,2-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid ALT: Alanine aminotransferases (ALT) AMPK: AMP activated protein kinase AST: Aspartate aminotransferase BAX: Bcl2-associated X protein CAT: Catalase CDK5: Cyclin-dependent kinase 5 CI: Confidence interval CK: Creatine kinase CRP: C-reactive proteins CVD: Cardiovascular disease DOCA: Deoxycorticosterone acetate EGF: Epidermal growth factor FRAP: Ferric reducing antioxidant power GGT: Glutamyltransferase GLUT4: Glucose transporter 4 GLP-1R: Glucagon-like peptide 1 receptor HCV: Hepatitis C virus hFEN1: Human flap endonuclease 1 IL: Interleukin IRS-1: Insulin receptor substrate-1 LDH: Lactate dehydrogenase LPS: Lipopolysaccharide MEK1: Mitogen-activated protein kinase 1 MIC: Minimum inhibitory concentration Nrf2: Nuclear factor erythroid 2-related factor PI3K: Phosphatidylinositol 3-kinase PKB: Protein kinase B PMA: Phorbol 12-myristate 13-acetate ROS: Reactive oxygen species SARS-CoV: Severe acute respiratory syndrome-coronavirus SOD: Superoxide dismutase SrtA: Sortase A STAT1: Signal transducer and activator of transcription 1 STZ: Streptozotocin TPA: 12-O-tetradecanoylphorbol-13-acetate RR: Relative risk References Matilla MA