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By reducing NNMT catalytic activity, the compound allows researchers to evaluate how limiting nicotinamide methylation influences: In vitro and in vivo experimental models (non-clinical, non-human) have demonstrated that NNMT suppression leads to measurable changes in cellular energy markers and adipocyte behavior
For these dogs, supplementing with cobalamin is usually indicated
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doi:10.1016/S0736-0266(03)00110-4 Bock-Marquette I, Saxena A, White MD, DiMaio JM, Srivastava D