Limitations of our study include that delineation of the mechanisms underlying improvement of systems metabolism by GLP-1GIPLani is challenging, not only because mice with germline deletion of PPAR or PPAR are embryonically lethal 28,29,50 , but also because targeting of both incretin receptors along with PPAR, PPAR or PPAR using conditional triple, quadruple or quintuple-knockout mice is beyond the possibilities of most scientific laboratories
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GLP-1, Metformin and rapamycin : three names that keep cropping up in the modern longevity conversation
31 Clinically, GLP-1 RA use in patients with diabetes is associated with significant primary risk reduction of several obesity-associated cancers
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Puigb et al., 2022)
