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The meaningful weight loss in the clinical trials (the 10 to 15 percent reduction in body weight seen over 68 weeks) happened at the 2.4 mg weekly dose (for Wegovy) or equivalent high-range doses in compound form

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The resolution of this paradox likely involves dose, individual neurological vulnerability, and the difference between GLP-1 receptor activation in different nervous system compartments

There are also medication alternatives for nausea management

Retatrutide reached 24.2% mean body-weight reduction at 12 mg/48 weeks in the Jastreboff et al

H., & Ahmad, F