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[27] In STEP UP T2D, semaglutide 7.2 mg produced greater weight loss than semaglutide 2.4 mg in adults with obesity and type 2 diabetes, with mean weight loss of 13.2% versus 10.4%, respectively

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Toxicology studies report no lethal dose, and clinical trials in other contexts (e.g., ulcerative colitis) noted no significant adverse effects