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AhR is essential for the differentiation and activation of Th17 cells (88)

This observation is in agreement with Hughes and Ottos findings where they observed the aggravation of anxiety by scopolamine in animal behavioral experiments (47)

Mechanically, tumor tissues tend to enhance their own antioxidant defenses in response to high levels of oxidative stress by up-regulating SLC7A11 expression, while SLC7A11-mediated synthesis of GSH acts as a defense against the cytotoxic effects of radiotherapy or certain drugs, which further reduces the sensitivity of tumor cells to treatment

Furthermore, oxidative stress arises from mitochondrial dysfunction and inflammation (Khan et al., 2022)