At the same time, levels of intracellular glutathione (GSH) deplete, reducing cells ability to defend against oxidative damage
DOI:10.1096/fj.201903119R Tiedge M., Lortz S., Drinkgern J., Lenzen S
Maintaining a healthy immune system is essential for healthy skin
Researchers administering cisplatin (5 mg/kg) to rats found marked toxic effects related to the dosage and timing in relation to their sexual cycle ( 4 Effective strategies to prevent the POF induced by cisplatin Due to the significant renal toxicity of cisplatin therapy, pre-treatment hydration therapy must be initiated before the treatment ( For gastrointestinal toxicity causing nausea and vomiting, antiemesis drugs can be used before the medication, a four-drug combination regimen consisting of NK1 receptor antagonist, 5-HT3 receptor antagonist, dexamethasone, and olanzapine has been recommended by the American Society of Clinical Oncology guidelines ( For hematological toxicity, granulocyte colony stimulating factor (G-CSF), recombinant human platelet growth factor, erythropoietin (EPO) and other drugs can be used to treat the symptoms, the chemotherapy doses can be adjusted, or blood transfusions may be required ( The neurotoxicity caused by cisplatin treatment cannot be avoided
Mitchell KG, Ikoma N, Nelson DB, Maru DM, Erasmus JJ, Weston BR, Vaporciyan AA, Antonoff MB, Mehran RJ, Rice DC, Roth JA, Swisher SG, Sepesi B, Walsh GL, Correa AM, Das P, Blum MA, Badgwell BD, Hofstetter WL
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