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In other words, youre not going to suddenly become pregnant, but if millions of people are taking it, and millions of women are on oral contraception, youre going to get a lot of unexpected babies, says Yeo

However, the question often arises from niche studies or specific physiological contexts

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doi: 10.1016/s0026-0495(97)90170-0

Key validation metrics include pharmacokinetics/pharmacodynamics concordance (e.g., clearance rates, area under the curve [AUC], metabolite formation), toxicological sensitivity and specificity, and the recapitulation of clinical-grade disease phenotypes and drug responses