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New strategies, including new forms of ERT, pharmacological chaperone therapy, substrate reduction therapy, and gene therapy, have been studied over the past decade

doi: 10.1038/s41584-018-0156-8 139 WangYCoughlinJMMaSEndresCJKassiouMSawaAet al

When GFAT is overexpressed in mice under the control of a GLUT4 promoter the animals develop classical insulin-resistant phenotype with hyperinsulinemia and reduction in whole-body glucose disposal rate

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CONCLUSION AND FURTHER PROSPECTS HMs toxicity is now a global problem for agricultural plants, soils, the environment, and human health

Anat Sci Int