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Although the underlying mechanisms by which arsenic causes such oxidative damage are not yet fully understood, possible mechanisms could include inhibition of antioxidant enzymes such as superoxide dismutase (SOD) and catalase, interface with cellular antioxidant defense systems by reducing levels of intracellular antioxidants such as glutathione, inhibition of DNA repair mechanisms, and alterations in epigenetic processes [7]

Talio MC, Luconi MO, Fernndez LP (2011) Determination of nickel in cigarettes smoke by molecular fluorescence

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This figure is determined using an ISO testing regime, an industry-standard in the EU and UK, and is based on the aerosol that is produced, rather than the content of sticks themselves