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Description

The BCF framework model revealed many clinical characteristics that predict glycemic responses with SGLT2i (prognostic factors) and multiple factors that predict differentiated glycemic responses with GLP1-receptor agonist versus SGLT2 inhibitor therapy (differential factors)

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Accordingly, whereas PPAR agonists (fibrates) are classically assumed to improve lipid and cholesterol metabolism via their action on the liver, agonists at PPAR (thiazolidinediones) are assumed to improve insulin sensitivity by enhancing adipose tissue differentiation and fatty acid uptake 10,11,23

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