OASIS trials: establishing effective doses Phase 2 OASIS 1 findings: Tested multiple dose levels: 0.3mg, 0.6mg, 1.2mg, 2.4mg, 4.5mg weekly Duration: 26 weeks Primary endpoint: Weight loss at each dose Dose-response results: 0.3mg weekly: ~4% body weight loss 0.6mg weekly: ~6% body weight loss 1.2mg weekly: ~8% body weight loss 2.4mg weekly: ~10% body weight loss 4.5mg weekly: ~12% body weight loss Key insight: Clear dose-response relationship
Peptide medications are complex to manufacture GLP-1 medicines are not produced in the same way as a simple conventional tablet
Mesotherapy: This skin whitening treatment uses a combination of vitamin C, glutathione and other antioxidants, which are injected into the skin using microneedles, microinjections, or electroporation
While generally well-tolerated, allergic reactions to tirzepatide can occur, ranging from mild injection site reactions to serious systemic hypersensitivity including anaphylaxis and angioedema
With so much emphasis placed on pre-workout supplementation, most people mail in their post-workout routine by taking the wrong products or even worse, not taking anything after a hard training session
Niu L et al (2021) Chronic sleep deprivation altered the expression of circadian clock genes and aggravated Alzheimer s disease neuropathology
