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This randomised, double-blind, placebo-controlled trial enrolled 706 adults with overweight or obesity (BMI 27 or above) across multiple dose groups, running over 26 weeks

(Clinical strategies for managing GI side effects).

The assay was validated according to local procedures: the FDA 2018 guideline on validation of bioanalytical methods [17], the EMA 2011 guideline on validation of bioanalytical methods [18] and current practice

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after 6 months, this increased to 10.9%

These combined effects lead to improved glycemic control in people with diabetes and significant weight reduction in those using it for obesity management