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Note, the cytoprotection concept made by Robert (prevention of stomach epithelial cell necrosis) [41,42,43,44] and Szabo (endothelium protection) [45,46,47,48,49,50] links the original protection of stomach epithelial cells to the protection of other organs (organoprotection) [42,47] (i.e., for eye pharmacotherapy, stomach epithelium behaves like eye epithelium [15]), and stomach-cytoprotective agents to agents with pleiotropic beneficial effect [42,47]

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The soluble mTORC1RHEB structure is in between the conformational pathway of the intermediate state and the fully active state when superimposed on the RHEB subunit (Extended Data Fig

Synthesis of Dimeric phenol derivatives and determination of in vitro antioxidant and radical scavenging activities