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Although no subgroup analysis was performed specifically for older adults, changes at the end of 24 weeks were reported to be independent of age [58]

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If GLP-1-GIP-Lani ever reaches the clinic, the relevant variants are likely to include rs10305420 in GLP1R (-0.76 kg additional weight loss per allele on GLP-1 monotherapy, per the 23andMe Nature paper from April 8, 2026), variants in GIPR tied to nausea and tolerability, and possibly variants in PPARG and PPARD that affect nuclear receptor signaling