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LCMS/MS was performed on an UltiMate 3000 nano-flow system (Dionex/LC Packings) connected to an LTQ Orbitrap hybrid mass spectrometer Velos FTMS (Thermo Fisher Scientific) equipped with a nano-electrospray ion source

(1) Over time, the body builds up a form of resistance, meaning the same dosage yields less impact than before, thus requiring increasing doses to achieve the same effect

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Introduction The Mechanism of Kidney Injury Caused by Drugs and Their Metabolites Biomarkers to Assess Nephrotoxicity References Further Reading Nephrotoxicity is defined as the rapid deterioration in kidney function as a result of medications and chemicals