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High concentrations of 4HNE have been associated with different processes such as apoptosis, cell differentiation, altered gene expression and with several diseases correlated to redox imbalance such as neurodegenerative and cardiovascular diseases, metabolic syndrome, and cancer 15

Kovacs-Nolan J 1 , Rupa P , Matsui T , Tanaka M , Konishi T , Sauchi Y , Sato K , Ono S , Mine Y

and this effect may be transient or may dissipate with longer term therapy

A Scaltec analytical balance was used to weigh the reagents